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AHC has new study published about antimicrobial resistance and the neonatal unit

Smit P, Stoesser N, Pol S, van Kleef E, Oonsivilai M, Tan P, et al. Transmission patterns of hyper-endemic multi-drug resistant Klebsiella pneumoniae in a Cambodian neonatal unit: a longitudinal study with whole genome sequencing. Front. Microbiol. 2018;9:1197.

Klebsiella pneumoniae can cause very serious infections in new born babies, especially those infants admitted to hospital in low- and middle-income countries. The bacterium is often resistant to many antibiotics, making it hard to treat. Klebsiella pneumoniae often lives harmlessly in the intestines of healthy individuals. However, it can spread between people and sometimes cause infection.

A study conducted at Angkor Hospital for Children in 2013-14 showed that babies were often already carrying Klebsiella pneumoniae in their intestines at the time of admission to the hospital’s newborn care unit. Non-colonised babies became carriers very soon after admission.

In this new publication we describe work done in partnership with researchers in Thailand and the UK to analyse further Klebsiella bacteria, collected the during 2013-14 study, using whole genome sequencing. We found that multiple strains (families) of the bacterium were circulating within and between patients in a very complex situation. There was no clear link between strains of the bacterium cultured from the ward environment and patients. Further work is being done to model how Klebsiella pneumoniae moves between patients to determine ways we might intervene to reduce the risk of infection.


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